Suppositories are spherical shaped solid dosage form of medicament meant for insertion into body cavities other than mouth. They are generally intended for use in the rectum, vagina, and to lesser extent, the urethra. Metronidazole is the FDA-approved drug for clinical use for the treatment of vaginal infections either alone or in combination with other antibiotics. Metronidazole is absorbed rapidly following oral administration producing peak plasma concentration within 1-2 hours with100% bioavailability. Elimination half life is 6-7 hours and is usually administered in a dose of 200-500 mg in order to maintain effective concentration throughout the day. So the present work involves use of suppositories which has no first pass effect. This will ensure minimum fluctuations in the plasma drug concentration and reduced dosing frequency which will result into improved patient compliance. The objective of the work is to Formulate and evaluate the Metronidazole containing cocoa butter suppositories, to study the effect of different surfactants and different concentration of individual surfactants on the drug release behavior. To perform stability studies as per ICH guidelines. The study has shown that different physical properties and release rates depends up on the formulation contents Tween 80, SLS and Span 20 at various levels are used for formulation studies. From the results it was conclude that Twee 80 has shown a considerable increase in disintegration and dissolution behavior and Sodium lauryl sulphate 2% has shown a good sustaining property for a period of 12 hours.
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